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2000
Volume 11, Issue 5
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

The synthesis of 2-[3/4-(2-substituted phenyl-2-oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1- one derivatives and the investigation of their anticancer activity were studied. 2-(3- or 4-Hydroxybenzylidene)-6- substituted-2,3-dihydro-1H-inden-1-ones were reacted with suitable 2-bromoacetophenones to give 2-[3/4-(2-substituted phenyl-2-oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one derivatives. The structure elucidation of the synthesised compounds was performed by IR, 1H-NMR, mass spectroscopic data and elemental analyses. The anticancer screening was carried out in National Cancer Institute (NCI), USA. Notable activity was obtained for some compounds.

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/content/journals/lddd/10.2174/1570180811666140403001212
2014-06-01
2025-06-01
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  • Article Type:
    Research Article
Keyword(s): 2; 3-Dihydro-1H-inden-1-one; Anticancer activity; Aurone analogue
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