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2000
Volume 11, Issue 8
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Sulfonate derivatives of estrone (E1) were designed and synthesized as potential reversible inhibitors of E1 sulfatase (ES). The results of the biochemical evaluation show the compounds to be weak inhibitors in comparison to the irreversible inhibitor E1-3-O-sulfamate, however, two compounds were found to possess good inhibitory activity.

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/content/journals/lddd/10.2174/1570180811666140226235116
2014-10-01
2025-07-03
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