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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Anticancer Activity and DNA Binding of 4-Alkylenediamines Modified Naphthalimide Derivatives
- Source: Letters in Drug Design & Discovery, Volume 11, Issue 6, Jul 2014, p. 742 - 748
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- 01 Jul 2014
Abstract
Four naphthalimide derivatives 2-5 modified with various alkylenediamines at 4-position have been designed and synthesized. Their anticancer activities were preliminarily evaluated, which showed potent anticancer activities against A549 cell line with IC50 values lower than 5 μM. Furthermore, the DNA binding properties of 2 with calf thymus (Ct) DNA were investigated by UV-Vis, fluorescence, and circular dichroism (CD) spectroscopies and thermal denaturation experiment. The results showed that compound 2 as the DNA intercalator exhibited strong binding affinity with Ct- DNA.
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