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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Biochemical Evaluation of a Range of 4-(n-alkanesulfonate) benzyl Imidazole-Based Compounds as Inhibitors of Rat Testicular 17α-hydroxylase/17,20-lyase (P45017) in the Treatment of Hormone- Dependent Prostate Cancer
- Source: Letters in Drug Design & Discovery, Volume 11, Issue 8, Oct 2014, p. 1000 - 1009
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- 01 Oct 2014
Abstract
17α-Hydroxylase/17,20-lyase is a target in the treatment of hormone-dependent prostate cancer. Here we report the results of a study into a range of alkanesulfonate derivatives of 4-hydroxybenzylimidazole which show the compounds to be good inhibitors with 5 [IC50=1.11μM (17α-OHase) and IC50=1.28μM (lyase)] being the most potent but weaker than ketoconazole.
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