Molecular Modeling and Ligand-Protein Interaction of N-Protein of Chandipura Virus

In different RNA viruses, the nucleocapsid protein N (N protein) plays an important functional role by enwrapping the viral genomic RNA in an RNase-resistant form. Targeting this essential protein is one of the best methods to find novel Chandipura virus (CHPV) inhibitors. The model of N protein of CHPV showed that this protein bears an alpha helical type topology. Computational characterization of N protein of CHPV exhibited that it bears DNA/ RNA binding region. Among all of the computationally screened compounds by GOLD, Flex X and ligandfit (DSv2.5) programs, antiviral compounds such as nelfinavir, acyclovir, azidothymidine are having very high binding affinity towards N protein of CHPV.