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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Anticonvulsant activity of Fluorinated Cyclic Enaminones
- Source: Letters in Drug Design & Discovery, Volume 10, Issue 10, Dec 2013, p. 1024 - 1031
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- 01 Dec 2013
Abstract
A series of novel fluorinated cyclic enaminone derivatives was synthesized and evaluated as potential anticonvulsants in four animal models of epilepsy, MES, ScPTZ, rotorod neurotoxicity and 6Hz assay. Phase I screening test data indicated significant anticonvulsant activity for compounds 2a, 4a, 4b, 7 and 8. Except for 2a and 4c all the above compounds showed protection with no observed neurotoxicity. Compound 8 exhibited continuous protection at four tested time in the 6 Hz assay with no overt toxicity.
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