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2000
Volume 11, Issue 1
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

A new series of resveratrol acrylamides amine derivatives was designed, synthesized, and evaluated for their anti-proliferative activity against three cancer cell lines including human chronic myelocytic leukemia cell K562, human hepatoma HuH-7 and human lung carcinoma A549. Most of the compounds showed superior activity against three cell lines when compared to parent resveratrol. C13 had the best anti-tumor activity against the HuH-7 cell line and its IC50 was 4.5 μmol/L; C16 had the best anti-tumor activity against the K562 cell line and its IC was 2.9 μmol/L; C18 had the best anti-tumor activity against the A549 cell line and its IC was 3.8 μmol/L. It could be seen that the activity of the aromatic amine derivatives was better than the fatty amine derivatives by analyzing the experimental data.

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/content/journals/lddd/10.2174/15701808113109990057
2014-01-01
2025-06-26
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