- ISSN: 1570-1808
- E-ISSN: 1875-628X
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s O-Arylation of Iodophenols with 2-Fluorobenzaldehyde Under Microwave Conditions
- Source: Letters in Drug Design & Discovery, Volume 11, Issue 1, Jan 2014, p. 114 - 120
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- 01 Jan 2014
Abstract
The arylation of 4-iodo-, 2-iodo- and 3-iodophenols with 2-fluorobenzaldehyde may be carried out in the presence of K2CO3 in DMF as the solvent under microwave conditions. The arylation of 4-iodophenole was promoted by the use of triethylbenzylammonium chloride (TEBAC) as the phase transfer catalyst. In the other model reactions, the use of TEBAC was harmful. By-products formed by isomerization and disproportionation were also detected.
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