-
s O-Arylation of Iodophenols with 2-Fluorobenzaldehyde Under Microwave Conditions
- Source: Letters in Drug Design & Discovery, Volume 11, Issue 1, Jan 2014, p. 114 - 120
-
- 01 Jan 2014
- Previous Article
- Table of Contents
- Next Article
Abstract
The arylation of 4-iodo-, 2-iodo- and 3-iodophenols with 2-fluorobenzaldehyde may be carried out in the presence of K2CO3 in DMF as the solvent under microwave conditions. The arylation of 4-iodophenole was promoted by the use of triethylbenzylammonium chloride (TEBAC) as the phase transfer catalyst. In the other model reactions, the use of TEBAC was harmful. By-products formed by isomerization and disproportionation were also detected.
© Bentham Science Publishers