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2000
Volume 11, Issue 4
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

A cost-effective and improved process was developed for the synthesis of the antiviral drug Valacyclovir hydrochloride 1. The process involves the Streglich condensation between 4 and 6 to obtain N-Phthalimide-L-Valine ester 5, which was deprotected by using 40% monomethylamine Overall, the chemistry has been developed and used to prepare Valacyclovir drug 1 in an overall yield of 61 %.

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/content/journals/lddd/10.2174/15701808113106660090
2014-05-01
2025-06-25
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