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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and In Vivo Hepatoprotective Activity of Some Novel Andrographolide Derivatives
- Source: Letters in Drug Design & Discovery, Volume 11, Issue 5, Jun 2014, p. 677 - 685
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- 01 Jun 2014
Abstract
In this study, combination-principle was reported to improve the hepatoprotective activity of andrographolide. Ten andrographolide derivatives were synthesized and evaluated for in vivo hepatoprotective activity in CCl4-induced liver injury mice. The pharmacological results revealed that 6 derivatives exhibited significant hepatoprotective activity. The most promising compound 6b significantly improved liver enzymes (ALT and AST) activity as compared with andrographolide, with high potency to be a new lead.
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