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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Semi-Synthesis of Caudatin Glycosides and Study on their Antiproliferative Activities
- Source: Letters in Drug Design & Discovery, Volume 9, Issue 8, Oct 2012, p. 775 - 779
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- 01 Oct 2012
Abstract
Four Caudatin glycosides were synthesized from Caudatin by reaction with tetra-O-actyl-D-glycosyl bromide catalyzed by CdCO3 and tested in vitro for their antiproliferative activities against human lung cancer A549, human prostate cancer PC3, human liver cancer BEL-7402 and human gastric cancer SGC-7901 cells. The IC50 values indicated that the inhibitory effect of Caudatin-tetra-O-actyl-D-glycosides was superior or comparable to Caudatin against most of the tested cells, worthy of further investigation.
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