Skip to content
2000
Volume 8, Issue 10
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

The combined activity of MGBG (metylglyoxal-bis(guanylhydrazone)) with either cisplatin or carboplatin was investigated, towards the human breast cancer cell line MCF-7. While a dose- and time-dependent cytotoxic activity was already observed for MGBG alone, a synergistic and non-reversible effect was verified upon co-administration with these Pt-based drugs. Furthermore, toxicity against non-neoplastic cells was shown to be quite low for these drug cocktails, as opposed to either Pt-agents alone. These results may hopefully allow to use lower dosages of both MGBG and the Ptdrugs, minimising the drug's deleterious side effects while keeping antitumour efficacy, in an anticancer strategy that couples interference with polyamine homeostasis with DNA damage.

Loading

Article metrics loading...

/content/journals/lddd/10.2174/157018011797655197
2011-12-01
2025-06-12
Loading full text...

Full text loading...

/content/journals/lddd/10.2174/157018011797655197
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test