Antimalarial Activity of an N-Alkyl Diamine

Nicolli B. de Souza; Carlos A. M. Rezende; Marcela S. Toledo; Davi C. Lagatta; Raphaela V. T. de Oliveira; Cristiane F. da Costa; Adilson D. da Silva; Marcio J. M. Alves; Sonia M. N. Cupolilo; Mauro V. de Almeida; Clarice Abramo

doi:10.2174/157018011794839439

ISSN: 1570-1808
E-ISSN: 1875-628X

Antimalarial Activity of an N-Alkyl Diamine
By Nicolli B. de Souza, Carlos A. M. Rezende, Marcela S. Toledo, Davi C. Lagatta, Raphaela V. T. de Oliveira, Cristiane F. da Costa, Adilson D. da Silva, Marcio J. M. Alves, Sonia M. N. Cupolilo, Mauro V. de Almeida and Clarice Abramo
Source: Letters in Drug Design & Discovery, Volume 8, Issue 4, May 2011, p. 371 - 374
DOI: https://doi.org/10.2174/157018011794839439
- Available online: 01 May 2011

Abstract

We report in this work the antimalarial activity of N-dodecyl-ethylenediamine (NDEDA). This compound was tested in vivo in a Plasmodium berghei murine model using the 4-day suppressive test in two separate experiments and displayed a very good inhibition of parasite multiplication.

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2011-05-01

2025-10-18

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Article Type: Research Article

Keyword(s): Antimalarial activity; Diamines; Infectious Diseases; Lethal; Malaria; Murine model; P. falciparum; P. malariae; P. Ovale; P. vivax; Plasmodium berghei; Polyamines; Protozoan Parasites; Trichomonas vaginalis; Trypanosoma cruzi

Antimalarial Activity of an N-Alkyl Diamine

Abstract

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