Synthesis and Biochemical Evaluation of a Series of Trifluoromethanesulfonate Derivatives of 4 Hydroxyphenyl Ketones – Probes of the Active Site of Type 1 and 3 of the 17β-Hydroxysteroid Dehydrogenase Family of Enzymes

In an effort to aid the design of dual-inhibitors of types 1 and 3 of the 17β-hydroxysteroid dehydrogenase (17β-HSD), we report the synthesis, biochemical evaluation and rationalisation of the inhibitory activity of trifluoromethanesulfonate derivatives of 4-hydroxyphenyl ketone-based compounds which were found to be weak inhibitors of types 1 and 3.