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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Biological Evaluation of a Range of Thiosemicarbazone - Based Compounds as Potential Inhibitors of Estrone Sulfatase (ES)
- Source: Letters in Drug Design & Discovery, Volume 8, Issue 3, Mar 2011, p. 241 - 245
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- 01 Mar 2011
Abstract
We report the initial results of our study into a series of thiosemicarbazone-based compounds as potential inhibitors of estrone sulfatase (ES). The results show the compounds to be weak inhibitors of ES in comparison to the standard estrone-3-O-sulfamate used within the study and which possessed 98 inhibition under similar conditions.
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