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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Microwave-Assisted Synthesis and Evaluation of Substituted Aryl Propyl Acridone-4-Carboxamides as Potential Chemosensitizing Agents for Cancer
- Source: Letters in Drug Design & Discovery, Volume 8, Issue 3, Mar 2011, p. 268 - 275
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- 01 Mar 2011
Abstract
A novel class of compounds with structure Aryl propyl acridone-4-carboxamides were synthesized by conventional and microwave (MW) irradiation methods and evaluated for their inhibitory effects on the transport activity of P- glycoprotein (P-gp) by standard Hoechst 33342 assay method. The title compounds with phenoxy substitution exhibited better activity.
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