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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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3-Substituted Isocoumarins as Thymidine Phosphorylase Inhibitors
- Source: Letters in Drug Design & Discovery, Volume 7, Issue 4, May 2010, p. 265 - 268
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- 01 May 2010
Abstract
3-Substituted isocoumarins 1-19 were synthesized and evaluated for their thymidine phosphorylase inhibitory activity. Eight (8) compounds exhibited a varying degree of inhibitory activity towards thymidine phosphorylase from E. coli with IC50 values between 61- 402 iM. The activities were compared with the standard 7-deazaxanthine (IC50 = 39.28 ± 0.76 iM).
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