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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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New Synthetic Chalcones: Cytotoxic Mannich Bases of 6-(4-Chlorocinnamoyl)-2(3H)-benzoxazolone
- Source: Letters in Drug Design & Discovery, Volume 5, Issue 6, Sep 2008, p. 358 - 361
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- 01 Sep 2008
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Abstract
A number of Mannich bases were synthesized by a reaction between 6-(4-chlorocinnamoyl)-2(3H)-benzoxazolone, formaldehyde and secondary amines. The structures of the compounds were confirmed by elemental analysis, IR and 1H-NMR spectra. The tested compounds exhibited concentration-dependent cytotoxic effects at low micromolar concentrations with IC50 values ranging between 1.4 and 30.9 μM.
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