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2000
Volume 5, Issue 6
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

PDK1 is pivotal in the development and progression of several cancers. A 3D pharmacophore was developed for pyrazole derivatives displaying anti-proliferative activity and PDK1 inhibition. The pharmacophore was utilized in the design of benzimidazole analogs. Our preliminary results indicate the pharmacophore should be useful in designing PDK1 inhibitors and anti-proliferative agents.

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/content/journals/lddd/10.2174/157018008785777324
2008-09-01
2025-06-12
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/content/journals/lddd/10.2174/157018008785777324
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  • Article Type:
    Research Article
Keyword(s): 3D Pharmacophore; Anti-proliferative; Benzimidazole; PDK1; Prostate cancer; SAR
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