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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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A Preliminary Assessment of the Structure-Activity Relationship of Benzimidazole-Based Anti-Proliferative Agents
- Source: Letters in Drug Design & Discovery, Volume 5, Issue 6, Sep 2008, p. 369 - 376
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- 01 Sep 2008
Abstract
PDK1 is pivotal in the development and progression of several cancers. A 3D pharmacophore was developed for pyrazole derivatives displaying anti-proliferative activity and PDK1 inhibition. The pharmacophore was utilized in the design of benzimidazole analogs. Our preliminary results indicate the pharmacophore should be useful in designing PDK1 inhibitors and anti-proliferative agents.
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