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2000
Volume 5, Issue 6
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

A number of urea derivatives were synthesized and screened for their urease and α-chymotrypsin inhibition effects, whereby one of the compounds, N-4-nitrophenyl-N’-4’-nitrophenylurea (3), showed strong urease inhibition (IC50 = 1.25μM). We found that the same compound is also an efficient α-chymotrypsin inhibitor having an IC50 value of 3.15μM.

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/content/journals/lddd/10.2174/157018008785777315
2008-09-01
2025-06-12
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/content/journals/lddd/10.2174/157018008785777315
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  • Article Type:
    Research Article
Keyword(s): Urea derivatives; Urease; α-chymotrypsin
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