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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Urease and α-Chymotrypsin Inhibitory Effects of Selected Urea Derivatives
- Source: Letters in Drug Design & Discovery, Volume 5, Issue 6, Sep 2008, p. 401 - 405
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- 01 Sep 2008
Abstract
A number of urea derivatives were synthesized and screened for their urease and α-chymotrypsin inhibition effects, whereby one of the compounds, N-4-nitrophenyl-N’-4’-nitrophenylurea (3), showed strong urease inhibition (IC50 = 1.25μM). We found that the same compound is also an efficient α-chymotrypsin inhibitor having an IC50 value of 3.15μM.
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