Antimicrobial Activities of 7-Aminosterol Squalamine Analogues

A series of new 7-aminosteroid derivatives were evaluated for their in vitro antimicrobial properties against human pathogens such as Gram positive bacteria. All the compounds present excellent activities against Gram-positive bacteria exhibiting similar results against Staphylococcus aureus and Streptococcus faecalis with MICs varying from 1.56 to 12.5 μg/mL. Moreover, all these considered derivatives possess MICs against Gram-negative Escherichia Coli bacteria (MIC varying from 2.5 to 10 μg/mL) making them particularly suitable for topical antibacterial use.