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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis of 5-Arylidene Barbiturates: A Novel Class of DPPH Radical Scavengers
- Source: Letters in Drug Design & Discovery, Volume 5, Issue 4, Jun 2008, p. 286 - 291
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- 01 Jun 2008
Abstract
Arylidene barbiturates 2-19 have been synthesized and their antioxidant and cytotoxic potentials have been evaluated. These compounds showed a moderate to excellent antioxidant activity in relevant antioxidant assay with no toxicity. A structure-activity relationship has been discussed. All the compounds were fully characterized by spectroscopic techniques.
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