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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Tetrahydroisoquinoline-Related Modulators of Multidrug Resistance in Cancer
- Source: Letters in Drug Design & Discovery, Volume 5, Issue 4, Jun 2008, p. 303 - 306
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- 01 Jun 2008
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Abstract
A series of novel tetrahydroisoquinoline derivatives (7a-b and 8a-j) were synthesized by using N-cyanoguanyl as a spacer, and their multidrug resistance reversal activities against K562/A02 cell line in vitro were evaluated by MTT method. It was found that 7a and 8b showed more potent multidrug resistance reversal activities than verapamil.
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