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2000
Volume 5, Issue 2
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Intramolecular N-7 alkylation of 6-substituted purines gave rise to a new series of tricyclic purine derivatives. The new compounds were evaluated for their cytotoxicity, their antileishmania activity together with their capacity to modulate NO production in macrophages. As a result compound 1 exhibited a modest activity against KB cells. On the other hand 4a was active against Leishmania and it diminished NO production of BCG-induced J774A.1 cells.

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/content/journals/lddd/10.2174/157018008783928535
2008-03-01
2025-06-11
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/content/journals/lddd/10.2174/157018008783928535
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  • Article Type:
    Research Article
Keyword(s): Anticancer; Antileishmania; NO production; Purine analogues
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