Synthesis and Evaluation of N-Aryl 2-Aminothiazole-4-Carboxamide Derivatives for Activity Against TB

Multi-drug resistant tuberculosis is a worldwide problem where despite treatment; mortality can range up to 18%. An N-aryl 2-aminothiazole-4-carboxamide derivative was identified as a lead compound in a Tuberculosis Coordinating Antimicrobial Acquisition Facility (TCAAF) screen. Synthesis and biological evaluation of additional analogs led to structure-activity relationships for activity against TB.