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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Isoform-Selective Regulation of Adenylyl Cyclase by Forskolin Derivatives:Prediction of Selectivity by Computer-Based Analysis
- Source: Letters in Drug Design & Discovery, Volume 4, Issue 6, Sep 2007, p. 434 - 441
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- 01 Sep 2007
Abstract
Adenylyl cyclase is a membrane-bound enzyme that catalyzes the conversion of ATP to cAMP upon various hormonal stimulations. Isoform-selectivity among forskolin derivatives that forskolin and its derivatives are a direct activator of adenylyl cyclase, can be predicted mostly by the distribution of the negative electrostatic potential of each derivative.
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