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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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The Molecular Basis of COX-2 Versus COX-1 Selectivity of Lumiracoxib by Molecular Docking Studies
- Source: Letters in Drug Design & Discovery, Volume 4, Issue 6, Sep 2007, p. 422 - 425
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- 01 Sep 2007
Abstract
A molecular rational basis for the COX-2/COX-1 selectivity of lumiracoxib using molecular docking approach is described. The COX-2 docking analysis for lumiracoxib and the diclofenac analogue revealed a similar binding mode, in contrast with the COX-1 docking analysis which revealed a different binding orientation for both inhibitors.
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