Synthesis and Biological Activities of New Triphenyl Organotin (IV) Based on the Pyrazole Carboxylic Acids

The synthesis of new triphenyltin derivatives with (N-substituted-pyrazol-3-yl) carboxylic acid fragments is described. The in vitro antibacterial activity of the new agents was evaluated against two fungal strains (Saccharomyces cerevisiae and Fusarium oxysporum f.sp albedinis) and against bacterial strains (Echerichia coli). A considerable activity was recorded with respect to the three studied micro-organisms. Structure activity relationship studies (SAR) reflect the effect of substituted pyrazolic fragment.