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2000
Volume 4, Issue 5
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

The present study examines the pharmacological profile of a new five indole derivatives 2a-e, ligands of the serotonin receptor evaluating the affinity for the serotoninergic, (5HT1A, 5HT2A and 5HT2C) receptors. The affinity of indole derivatives 2a-e (10-6-5x10-7-10-7 M) for receptors is defined as inhibition percentage of radioligand/receptor binding and measured as the radioactivity of remaining complex radioligand/receptor. The results of our experiments indicate that compounds 2a and 2e show high affinity for the 5-HT2A receptors; compounds 2b and 2c show high affinity for the 5-HT1A receptors and compound 2d shows high affinity for the 5-HT2C receptors. Results of computational chemistry suggest that the presence of a methoxyl group in 6 on the indole system is necessary for the serotoninergic activity.

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/content/journals/lddd/10.2174/157018007780867861
2007-07-01
2025-06-12
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/content/journals/lddd/10.2174/157018007780867861
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  • Article Type:
    Research Article
Keyword(s): Binding studies; Indole derivatives; Serotoninegic system
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