Synthesis and Antitumor Activity of Novel Pentacyclic Triterpenoid Lantadene D

Manu Sharma; Pritam Dev Sharma; Mohinder Pal Bansal; Jaswant Singh

doi:10.2174/157018007780077471

ISSN: 1570-1808
E-ISSN: 1875-628X

Synthesis and Antitumor Activity of Novel Pentacyclic Triterpenoid Lantadene D
Authors: Manu Sharma¹, Pritam Dev Sharma², Mohinder Pal Bansal³ and Jaswant Singh⁴
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¹ University Institute of Pharmaceutical Sciences, Panjab University Chandigarh- 160014, India. ² University Institute of Pharmaceutical Sciences, Panjab University Chandigarh- 160014, India. ³ University Institute of Pharmaceutical Sciences, Panjab University Chandigarh- 160014, India. ⁴ University Institute of Pharmaceutical Sciences, Panjab University Chandigarh- 160014, India.
Source: Letters in Drug Design & Discovery, Volume 4, Issue 3, Apr 2007, p. 201 - 206
DOI: https://doi.org/10.2174/157018007780077471
- Available online: 01 Apr 2007

Abstract

Lantadene D was semi-synthetically prepared by functionalizing 22β-hydroxyoleanonic acid and screened for cytotoxicity against four human cancer cell lines (HL-60, HeLa, Colon 502713 and Lung A-549). It was further evaluated for its inhibitory profile against two-stage carcinogenesis in Swiss albino mice.

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2007-04-01

2025-06-01

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Article Type: Research Article

Keyword(s): 12-O- Tetradecanoylphorbol-13 acetate (TPA); 7, 12-Dimethylbenz [a] anthracene (DMBA); Antitumor; Cytotoxicity; Lantadene D

Synthesis and Antitumor Activity of Novel Pentacyclic Triterpenoid Lantadene D

Abstract

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