Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides

T. G. Tolstikova; A. O. Bryzgalov; I. V. Sorokina; M. V. Hvostov; A. S. Ratushnyak; T. A. Zapara; O. G. Simonova

doi:10.2174/157018007780077453

ISSN: 1570-1808
E-ISSN: 1875-628X

Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides
Authors: T. G. Tolstikova¹, A. O. Bryzgalov², I. V. Sorokina³, M. V. Hvostov⁴, A. S. Ratushnyak⁵, T. A. Zapara⁶ and O. G. Simonova⁷
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¹ Novosibirsk N.N.Vorozhtsov Institute of Organic Chemistry Siberian branch of RAS.630090, Lavrentyev Av 9, Novosibirsk, Russia. ² Novosibirsk N.N.Vorozhtsov Institute of Organic Chemistry Siberian branch of RAS.630090, Lavrentyev Av 9, Novosibirsk, Russia. ³ Novosibirsk N.N.Vorozhtsov Institute of Organic Chemistry Siberian branch of RAS.630090, Lavrentyev Av 9, Novosibirsk, Russia. ⁴ Novosibirsk N.N.Vorozhtsov Institute of Organic Chemistry Siberian branch of RAS.630090, Lavrentyev Av 9, Novosibirsk, Russia. ⁵ Novosibirsk N.N.Vorozhtsov Institute of Organic Chemistry Siberian branch of RAS.630090, Lavrentyev Av 9, Novosibirsk, Russia. ⁶ Novosibirsk N.N.Vorozhtsov Institute of Organic Chemistry Siberian branch of RAS.630090, Lavrentyev Av 9, Novosibirsk, Russia. ⁷ Novosibirsk N.N.Vorozhtsov Institute of Organic Chemistry Siberian branch of RAS.630090, Lavrentyev Av 9, Novosibirsk, Russia.
Source: Letters in Drug Design & Discovery, Volume 4, Issue 3, Apr 2007, p. 168 - 170
DOI: https://doi.org/10.2174/157018007780077453
- Available online: 01 Apr 2007

Abstract

The effect of pharmacones clathration with glycosides results in significant decrease of drug agent dosage. We investigated the clathrates of hypotensive agent Nifedipine with glycyrrhizic acid, which was prepared in molecular proportion 1:4 respectively. Present study was carried out on the calcium channels on neurons of Lymnaea stagnalis mollusc.

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2007-04-01

2025-06-14

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Article Type: Research Article

Keyword(s): Calcium channels; Glycyrrhizic acid; Nifedipine; Pharmacones clathration

Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides

Abstract

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