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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Sodium Proton Exchanger Inhibitor in Ischemia/Reperfusion Injury in the Heart Surgery: Controversy in Clinical Application
- Source: Letters in Drug Design & Discovery, Volume 4, Issue 1, Jan 2007, p. 9 - 14
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- 01 Jan 2007
Abstract
The Na+-HCO3 - symport plays as significant role as the Na+/H+ exchanger in ischemia/reperfusion injury. Under bicarbonate free conditions, however, the Na+-HCO3 - symport does not work, and so the protective efficacy of Na+/H+ exchanger inhibitors is overestimated. We discuss the reasons for the inconsistencies in studies of the Na+/H+ exchanger.
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