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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Biological Evaluation of Coumarin Linked Fluoroquinolones, Phthalimides and Naphthalimides as Potential DNA Gyrase Inhibitors
- Source: Letters in Drug Design & Discovery, Volume 3, Issue 7, Sep 2006, p. 494 - 502
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- 01 Sep 2006
Abstract
A hybrid molecule synthesis strategy is employed to develop new molecules with potential antibacterial activity. Three types of coumarin-linked hybrids have been synthesized. The coumarin ring system has been linked to phthalimido, naphthalimido and quinolone moieties at 4-position through piperazino alkane spacers. These compounds have been evaluated for their antibacterial activity. Some of these new hybrids particularly phthalimido and naphthalimido ones have exhibited DNA gyrase inhibition activity.
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