Identification of Privileged Scaffolds from a Diversified Chemical Library forβ-Secretase Inhibition

Nicolas Pietrancosta; Gilles Quelever; Cedrik Garino; Younes Laras; Stephane Burlet; Jean-Louis Kraus

doi:10.2174/157018005774717352

ISSN: 1570-1808
E-ISSN: 1875-628X

Identification of Privileged Scaffolds from a Diversified Chemical Library forβ-Secretase Inhibition
Authors: Nicolas Pietrancosta¹, Gilles Quelever², Cedrik Garino³, Younes Laras⁴, Stephane Burlet⁵ and Jean-Louis Kraus⁶
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¹ Laboratoire de Chimie Biomoleculaire - INSERM U-623, Faculte des Sciences de Luminy, case 907, 13288 Marseille Cedex 09, France. ² Laboratoire de Chimie Biomoleculaire - INSERM U-623, Faculte des Sciences de Luminy, case 907, 13288 Marseille Cedex 09, France. ³ Laboratoire de Chimie Biomoleculaire - INSERM U-623, Faculte des Sciences de Luminy, case 907, 13288 Marseille Cedex 09, France. ⁴ Laboratoire de Chimie Biomoleculaire - INSERM U-623, Faculte des Sciences de Luminy, case 907, 13288 Marseille Cedex 09, France. ⁵ Laboratoire de Chimie Biomoleculaire - INSERM U-623, Faculte des Sciences de Luminy, case 907, 13288 Marseille Cedex 09, France. ⁶ Laboratoire de Chimie Biomoleculaire - INSERM U-623, Faculte des Sciences de Luminy, case 907, 13288 Marseille Cedex 09, France.
Source: Letters in Drug Design & Discovery, Volume 2, Issue 8, Dec 2005, p. 595 - 600
DOI: https://doi.org/10.2174/157018005774717352
- Available online: 01 Dec 2005

Abstract

A privileged structure has been identified within the 1,300-member diversified library by rational selection of the compounds to be tested prior to the screening towards enzymatic β-secretase (BACE-1) assay. The identified hexahydrobenzothiazole privileged structure has been optimised and a preliminary structureactivity study has been performed.

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2005-12-01

2025-05-25

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Article Type: Review Article

Keyword(s): Alzheimer's disease; Diversified chemical library; hexahydrobenzothiazole; privileged structure; screening; β-secretase (BACE-1)

Identification of Privileged Scaffolds from a Diversified Chemical Library forβ-Secretase Inhibition

Abstract

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