Symmetrical Derivatives with Nitrogenated Functions as Cytotoxic Agents and Apoptosis Inducers

The synthesis and some pharmacological properties of new symmetrical compounds are described. The cytotoxicity, apoptosis induction and caspase-3 activation of the synthesized compounds have been evaluated against three human cancer cell lines. Compounds that showed cytotoxic activity were tested as proapoptotic and caspase-3 activators. Some of the compounds showed interesting values as apoptosis inducers and caused a notable increase in caspase-3 levels.