Aromatic Polycationic Molecules with Restricted Conformations: An Alternative Approach to Antiherpes Agents

Andrew Tsotinis; Margarita Vlachou; Andreas Eleutheriades; Peter J. Garratt; Ashley J. Ibbett; Yiu-Fai Ng; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq

doi:10.2174/1570180054405758

ISSN: 1570-1808
E-ISSN: 1875-628X

Aromatic Polycationic Molecules with Restricted Conformations: An Alternative Approach to Antiherpes Agents
Authors: Andrew Tsotinis¹, Margarita Vlachou², Andreas Eleutheriades³, Peter J. Garratt⁴, Ashley J. Ibbett⁵, Yiu-Fai Ng⁶, Christophe Pannecouque⁷, Myriam Witvrouw⁸ and Erik De Clercq⁹
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¹ Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece; ² Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece; ³ Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece; ⁴ Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece; ⁵ Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece; ⁶ Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece; ⁷ Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece; ⁸ Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece; ⁹ Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece;
Source: Letters in Drug Design & Discovery, Volume 2, Issue 5, Aug 2005, p. 424 - 427
DOI: https://doi.org/10.2174/1570180054405758
- Available online: 01 Aug 2005

Abstract

A series of aromatic polycationic molecules were synthesised and tested as potential non-classical antiherpes agents. Analogue (4) had a high potency in all four of the HSV cell lines used and is far more potent than ribavirin. The fact that none of the new compounds show any selectivity for HSV-2 over HSV-1 may imply that there is no intervention of a HSV-2 glycoprotein C (gC) dependent pathway.

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2005-08-01

2025-05-28

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Article Type: Review Article

Keyword(s): antiherpes activity; polypodand aromatic cations; synthesis

Aromatic Polycationic Molecules with Restricted Conformations: An Alternative Approach to Antiherpes Agents

Abstract

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