Pituitary Adenylate Cyclase Activating Polypeptide in Animal Models of Neurodegenerative Disorders - Implications for Huntington and Parkinson's Diseases

D. Reglodi; A. Tamas; A. Somogyvari-Vigh

doi:10.2174/1570180054038440

ISSN: 1570-1808
E-ISSN: 1875-628X

Pituitary Adenylate Cyclase Activating Polypeptide in Animal Models of Neurodegenerative Disorders - Implications for Huntington and Parkinson's Diseases
Authors: D. Reglodi¹, A. Tamas² and A. Somogyvari-Vigh³
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¹ Tulane University School of Medicine, Department of Medicine, 1430 Tulane Avenue SL-35, New Orleans, LA 70112, USA. ² Tulane University School of Medicine, Department of Medicine, 1430 Tulane Avenue SL-35, New Orleans, LA 70112, USA. ³ Tulane University School of Medicine, Department of Medicine, 1430 Tulane Avenue SL-35, New Orleans, LA 70112, USA.
Source: Letters in Drug Design & Discovery, Volume 2, Issue 4, Jun 2005, p. 311 - 315
DOI: https://doi.org/10.2174/1570180054038440
- Available online: 01 Jun 2005

Abstract

The present study summarizes results obtained with PACAP treatment in models of neurodegenerative diseases. The data show that PACAP protected a significant number of neurons in quinolinic acid- and 6-hydoxydopamine-induced lesions, which correlated with the less severe behavioral symptoms. These effects may have clinical implications in Huntington and Parkinson's diseases.

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2005-06-01

2025-05-28

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Article Type: Review Article

Keyword(s): huntington; neurodegeneration; neuroprotection; pacap; parkinson

Pituitary Adenylate Cyclase Activating Polypeptide in Animal Models of Neurodegenerative Disorders - Implications for Huntington and Parkinson's Diseases

Abstract

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