Computational Studies of 1-Hydrazinophthalazine (Hydralazine) as Antineoplasic Agent. Docking Studies on Methyltransferase

Enrique Angeles; Victor HugoVazquez-Valadez; Oscar Vazquez-Valadez; Ana M. Velazquez-Sanchez; Alberto Ramirez; Luisa Martinez; Sandra Diaz-Barriga; Andres Romero-Rojas; Gustavo Cabrera; Rafael Lopez-Castanares; Alfonso Duenas-Gonzalez

doi:10.2174/1570180054038413

ISSN: 1570-1808
E-ISSN: 1875-628X

Computational Studies of 1-Hydrazinophthalazine (Hydralazine) as Antineoplasic Agent. Docking Studies on Methyltransferase
Authors: Enrique Angeles¹, Victor HugoVazquez-Valadez², Oscar Vazquez-Valadez³, Ana M. Velazquez-Sanchez⁴, Alberto Ramirez⁵, Luisa Martinez⁶, Sandra Diaz-Barriga⁷, Andres Romero-Rojas⁸, Gustavo Cabrera⁹, Rafael Lopez-Castanares¹⁰ and Alfonso Duenas-Gonzalez¹¹
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¹ Laboratorio de Quimica Medicinal., Campo 1, FESC-UNAM, Cuautitlan Izcalli, Estado de Mexico, Mexico, CP 54740. ² Laboratorio de Quimica Medicinal., Campo 1, FESC-UNAM, Cuautitlan Izcalli, Estado de Mexico, Mexico, CP 54740. ³ Laboratorio de Quimica Medicinal., Campo 1, FESC-UNAM, Cuautitlan Izcalli, Estado de Mexico, Mexico, CP 54740. ⁴ Laboratorio de Quimica Medicinal., Campo 1, FESC-UNAM, Cuautitlan Izcalli, Estado de Mexico, Mexico, CP 54740. ⁵ Laboratorio de Quimica Medicinal., Campo 1, FESC-UNAM, Cuautitlan Izcalli, Estado de Mexico, Mexico, CP 54740. ⁶ Laboratorio de Quimica Medicinal., Campo 1, FESC-UNAM, Cuautitlan Izcalli, Estado de Mexico, Mexico, CP 54740. ⁷ Laboratorio de Quimica Medicinal., Campo 1, FESC-UNAM, Cuautitlan Izcalli, Estado de Mexico, Mexico, CP 54740. ⁸ Laboratorio de Quimica Medicinal., Campo 1, FESC-UNAM, Cuautitlan Izcalli, Estado de Mexico, Mexico, CP 54740. ⁹ Laboratorio de Quimica Medicinal., Campo 1, FESC-UNAM, Cuautitlan Izcalli, Estado de Mexico, Mexico, CP 54740. ¹⁰ Laboratorio de Quimica Medicinal., Campo 1, FESC-UNAM, Cuautitlan Izcalli, Estado de Mexico, Mexico, CP 54740. ¹¹ Laboratorio de Quimica Medicinal., Campo 1, FESC-UNAM, Cuautitlan Izcalli, Estado de Mexico, Mexico, CP 54740.
Source: Letters in Drug Design & Discovery, Volume 2, Issue 4, Jun 2005, p. 282 - 286
DOI: https://doi.org/10.2174/1570180054038413
- Available online: 01 Jun 2005

Abstract

Hydralazine is a drug used as anti-hypertensive, and recently reported to be a DNA methylation inhibitor able to demethylate and reactivate the expression of tumor suppressor genes in cancer. The aim of the present study was to explore the potential mechanism by which hydralazine inhibits DNA methylation. For this purpose, we assessed the structural and electronic properties between 1-hydrazinophthalazine (hydralazine) and a putative ligand methyltransferase.

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2005-06-01

2025-05-26

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Article Type: Review Article

Keyword(s): dna methylation inhibitor; dna methyltransferase; docking; hydralazine; tumor suppressor gene

Computational Studies of 1-Hydrazinophthalazine (Hydralazine) as Antineoplasic Agent. Docking Studies on Methyltransferase

Abstract

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