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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Inhibition of Transforming Growth Factor- βActivation is a Novel Effect of Chymase Inactivation
- Source: Letters in Drug Design & Discovery, Volume 2, Issue 1, Feb 2005, p. 19 - 22
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- 01 Feb 2005
Abstract
Chymase activates latent transforming-growth factorβ to transforming-growth factorβ in vitro. Recent papers demonstrate that transforming-growth factorβ levels and tissue fibrosis were significantly reduced by chymase inhibitors in the experimental models. Thus, transforming-growth factorβ-related diseases such as fibrosis may become a novel target of chymase inhibitors.
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