Pharmacological Profile of New Deamino Analogues of Sabarubicin (MEN 10755)

M. Bigioni; C. Salvatore; A. Cipollone; M. Berettoni; C. A. Maggi; M. Binaschi

doi:10.2174/1570180053398307

ISSN: 1570-1808
E-ISSN: 1875-628X

Pharmacological Profile of New Deamino Analogues of Sabarubicin (MEN 10755)
Authors: M. Bigioni¹, C. Salvatore², A. Cipollone³, M. Berettoni⁴, C. A. Maggi⁵ and M. Binaschi⁶
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¹ Department of Pharmacology, Menarini Ricerche, S.p.A., Via Tito Speri 10, 00040 Pomezia, Italy. ² Department of Pharmacology, Menarini Ricerche, S.p.A., Via Tito Speri 10, 00040 Pomezia, Italy. ³ Department of Pharmacology, Menarini Ricerche, S.p.A., Via Tito Speri 10, 00040 Pomezia, Italy. ⁴ Department of Pharmacology, Menarini Ricerche, S.p.A., Via Tito Speri 10, 00040 Pomezia, Italy. ⁵ Department of Pharmacology, Menarini Ricerche, S.p.A., Via Tito Speri 10, 00040 Pomezia, Italy. ⁶ Department of Pharmacology, Menarini Ricerche, S.p.A., Via Tito Speri 10, 00040 Pomezia, Italy.
Source: Letters in Drug Design & Discovery, Volume 2, Issue 1, Feb 2005, p. 68 - 73
DOI: https://doi.org/10.2174/1570180053398307
- Available online: 01 Feb 2005

Abstract

Sabarubicin (MEN 10755) is the progenitor of a third generation of synthetic anthracycline oligosaccharides. Sabarubicin deamino analogues MEN 10959 and MEN 12297 were evaluated for topoisomerase II poisoning, cytotoxic potency and antitumor activity in human xenografts. The new analogues were able to induce DNA cleavage mediated by both DNA topoisomerase IIα and β and a good correlation was found regarding their cytotoxic activity. The two analogues possess also a different spectrum of antitumor activity, compared to sabarubicin.

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2005-02-01

2025-05-29

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Article Type: Review Article

Keyword(s): anthracycline disaccharides; dna topoisomerase; men 10755; men 10959; men 12297; sabarubicin

Pharmacological Profile of New Deamino Analogues of Sabarubicin (MEN 10755)

Abstract

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