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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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2,3,4,5- Tetrahydro- 1-Benzoxepines a Novel Class of Anti-Implantation Agents
- Source: Letters in Drug Design & Discovery, Volume 2, Issue 1, Feb 2005, p. 36 - 39
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- 01 Feb 2005
Abstract
5- Substituted 2,3,4,5- Tetrahydro- 1-benzoxepine derivatives have been synthesized as novel antiimplantation agents. The synthesized compounds were evaluated for their anti-implantation activity in mature female Sprague-Dawley rats. The most active compounds in this series 10d and 11d, are 67% active in preventing implantation in rats at 10 mgkg-1 dose. We also found that the other compounds of the series have lesser anti-implantation activity compared to the most potent anti-implantation drug Centchroman 5.
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