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Volume 21, Issue 19
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Introduction

Dermatophytosis is a significant global health issue that poses a serious risk to public well-being. This fungal infection occurs when dermatophytes invade the outer surfaces of both human and animal bodies. The use of common anti-dermatophyte medications has some limitations due to their side effects and drug resistance. Herbal remedies offer broad-spectrum antimicrobial effects low toxicity, and are widely used compared to traditional chemical fungicides. Recent studies have indicated that the ozone has antifungal activity due to its high oxidizing power and skin penetrating capacity.

Methods

This study examined the antifungal effects of ozonated olive oil in treating dermatophytosis caused by through and tests on rats. The agar dilution method was used to establish the treatments' minimum inhibitory concentrations (MICs). For the study, thirty male Wistar albino rats from the Laboratory Animal Unit were prepared. The topical antifungals were then applied topically once daily for 7 days to the animals beginning 10 days after the appearance of symptoms. Five groups of animals were treated with virgin olive oil, ozonated olive oil (1.25, 2.5, or 5 mg/mL), and terbinafine (1.25 g/mL).

Results

Following the therapy period, clinical and mycological efficacies were assessed. Ozonated olive oil and terbinafine were shown to have MIC of 2.5 µg/mL and 0.62 µg/mL against , respectively. Ozonated olive oil showed antifungal effects and significantly reduced the clinical score by increasing hair growth and decreasing inflammation, similar to terbinafine.

Conclusion

Therefore, ozonated olive oil may serve as an alternative treatment for infections.

© 2024 Bentham Science Publishers
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2025-01-22
2025-05-14

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Efficacy of Ozonated Olive Oil as a Topical Treatment for Dermatophytosis Caused by T. mentagrophytes in Rat Model
Letters in Drug Design & Discovery 21, 4826 (2024); https://doi.org/10.2174/0115701808337824250103053527
/content/journals/lddd/10.2174/0115701808337824250103053527
/content/journals/lddd/10.2174/0115701808337824250103053527
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  • Article Type:     Research Article
Keyword(s): antifungal; dermatophytes; Dermatophytosis; mycological efficacy; ozonated olive oil; terbinafine

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