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Volume 21, Issue 19
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background

Eudragit L100, filled with miconazole and gelatinous polymeric eye drops, is designed to sustain the drug release and increase ocular effect.

Methods

The solvent diffusion technique was used to obtain the polymeric solution. The formulations developed were fully characterized and examined.

Results

The optimized drug had a particle size of 71.15 2.3 nm, a zeta potential of approx. 2.57 to 0.76 mV, a polydispersity index of approx. 0.184 and a capture efficiency of 0.10% of 58.049. The prepared efforts showed a fungicidal effect on cultures.

Conclusion

The polymeric solution containing the drug-filled with miconazole (MZ) showed an abrupt release in the first hours, followed by the pattern of sustained drug release. A higher cumulative corneal permeability was observed from MZ-containing polymeric solution, which prolonged MZ release in goat eyes. Mucoadhesive liners containing miconazole-loaded Eudragit L100 polymeric solution provide a promising approach to the ocular administration of miconazole (a fungicide) for the treatment of ocular infections requiring long-term drug administration.

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2025-01-13
2025-05-11

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/content/journals/lddd/10.2174/0115701808301816241029103316
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Physically Crosslinked Polymeric Network for Controlled and Mucoadhesive Release of Miconazole for Topical Ocular Delivery
Letters in Drug Design & Discovery 21, 4698 (2024); https://doi.org/10.2174/0115701808301816241029103316
/content/journals/lddd/10.2174/0115701808301816241029103316
/content/journals/lddd/10.2174/0115701808301816241029103316
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  • Article Type:     Research Article
Keyword(s): controlled drug delivery; eudragitL100; gelatin; long-term drug administration; Miconzazole; topical ocular delivery

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