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- Volume 24, Issue 4, 2024
Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) - Volume 24, Issue 4, 2024
Volume 24, Issue 4, 2024
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Triple Burden: The Incorrigible Threat of Tuberculosis, HIV, and COVID-19
Authors: Parakriti Gupta, Diljot Sandhu, Varsha Gupta and Lipika SinghalThe Coronavirus-19 (COVID-19) hasn’t seen the dawn since its emergence, however waxing and waning has resulted in the emergence of deadly variants. The effects of pandemic have not been limited to its virulence, but have rather conferred multiple collateral effects, especially in developing countries; thereby, designating it as a SYNDEMIC. The same culminated in neglect of non-COVID-19 conditions like tuberculo Read More
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Ochrobactrum Anthropi; an Unusual Cause of Bacteremia and Pneumonia: A Case Report and a Brief Review of the Literature
Authors: Zefr Chao, Anaam Fayyaz and Suresh AntonyBackground: Ochrobactrum anthropi spp. is a non-enteric, aerobic gram-negative bacillus that has been reported to cause sepsis and occasionally bacteremia in both immunocompetent and immunocompromised hosts. This bacterium is capable of surviving in various habitats, but due to its affinity for aqueous environments, O. anthropi is hypothesized to have an affinity for indwelling plastic devices and other foreign bodies. Read More
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Diagnosis and Management of Latent Tuberculosis Infection: Updates
India has the largest problem of tuberculosis (TB) infection globally (estimated at about 35-40 crores cases), and around 18-36 lakh develop active tuberculosis annually. Latent TB is defined as a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens with no evidence of clinically manifested active TB. The progression of a latent infection to active tuberculosis increases several-fold in children Read More
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The Re-emergence of Diphtheria Amidst Multiple Outbreaks in Nigeria
Diphtheria, a vaccine-preventable disease, has resurfaced in Nigeria, where many outbreaks have been reported in recent years. The outbreaks have occurred across the country, including in areas with high vaccination coverage. Corynebacterium diphtheriae, the causal agent, is a highly contagious bacteria that can cause severe respiratory and systemic symptoms and can be fatal if not treated. The reemergence of diph Read More
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A Novel Potential Treatment for Diabetic Foot Ulcers and Non-Healing Ulcers - Case Series
Authors: Sarabpreet Singh, Arun Kumar Aggarwal, Rajendra Gudisa, Priyam Batra, Nitesh Kumar Rathi, Vibha Madan, Vipul Thakur, Harish Sharma, Rajesh Kumar, Siddhant Khare, Lipika Singhal, Rama Chaudhry, Neeraj Arora, Hardeep Singh, Jasjeet Kaur, Ashish Sharma, Ganesh N. Dakhale, Vijay Sharma and Vikas GautamIntroduction: Appropriate care and treatment of a wound is the need of the hour whether it is an infected or a non-infected wound. If wound healing is delayed for some reason, it leads to serious complications and further increases the hospital stay and cost of treatment. Herein, we describe a novel antimicrobial wound dressing formulation (VG111), with an objective to generate the preliminary data showing the disti Read More
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Perspective of Secondary Metabolites in Respect of Multidrug Resistance (MDR): A Review
Authors: Aditi Kaushik, Manish Kaushik, Gagandeep Kaur and Vrinda GuptaAberrant and haphazard use of antibiotics has created the development of antimicrobial resistance which is a bizarre challenge for human civilization. This emerging crisis of antibiotic resistance for microbial pathogens is alarming all the nations posing a global threat to human health. It is difficult to treat bacterial infections as they develop resistance to all antimicrobial resistance. Currently used antibacterial agents inhibi Read More
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Fusobacterium/Peptostreptococcus - A Case Report of Community- Acquired Empyema Resulting in Surgical Decortication with Prolonged Antibiotic Therapy: A Case Series and Review of the Literature
Authors: Garrastegui-Mercado Emmanuel, Awad Chady and Suresh AntonyBackground: Infections caused by anaerobic bacteria occur frequently and can be serious and life-threatening. Anaerobes are a rare cause of community-acquired pneumonia with Streptococcus pneumonia and respiratory viruses being the most frequently detected pathogens. We, herein, report a case of Fusobacterium/Peptostreptococcus parapneumonic effusion with empyema in a patient without risk factors for aspiratio Read More
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Rapidly Evolving SARS-CoV-2: A Brief Review Regarding the Variants and their Effects on Vaccine Efficacies
Authors: Shahid Nawaz, Sara Janiad, Aiman Fatima, Maira Saleem, Urooj Fatima and Asad AliSince the commencement of Corona Virus Disease 2019 (COVID-19) pandemic, which has resulted in millions of mortalities globally, the efforts to minimize the damages have equally been up to the task. One of those efforts includes the mass vaccine development initiative targeting the deadly Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). So far, vaccines have tremendously decreased the rate of transmissio Read More
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A Retrospective Study Comparing Mortality Rates between Vaccinated and Unvaccinated Kidney Transplant Recipients
Authors: Anaam Fayyaz, Judy Pozzerle and Suresh J. AntonyBackground: With the emergence of vaccines for COVID-19, mortality and severity of disease have decreased. However, patients with certain comorbidities, such as immunosuppression, CKD, and renal transplant, still have higher mortality rates as compared to the general population. Current data suggests that the risk of developing COVID-19 among transplant patients was reported to be about 5%, which is significantl Read More
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Monkeypox Virus (MPXV) Infection: A Review
Authors: Rosy Kumari, Pooja Arya, Surya P. Yadav, Ratish Chandra Mishra and Jaya Parkash YadavMonkeypox is a viral disease; its outbreak was recently declared a global emergency by the World Health Organization. For the first time, a monkeypox virus (MPXV)-infected patient was found in India. Various researchers back-to-back tried to find the solution to this health emergency just after COVID-19. In this review, we discuss the current outbreak status of India, its transmission, virulence factors, symptoms, treatm Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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