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- Volume 23, Issue 7, 2023
Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) - Volume 23, Issue 7, 2023
Volume 23, Issue 7, 2023
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The Use of Remdesivir in Patients with COVID-19
Remdesivir has appeared to be the most effective medication against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and is broadly administered to coronavirus disease 2019 (COVID-19) patients around the world. Remdesivir is an RNA polymerase inhibitor with a broad spectrum of antiviral activities against RNA viruses in in-vitro and in-vivo models of SARSCoV, the Middle East respiratory syndrom Read More
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Bacterial Persister Cells: Mechanisms of Formation, Control, and Eradication
Bacterial Persister Cells (BPCs) are quiescent, slow-growing or growth-arrested phenotypic variants of normal bacterial cells that are transiently tolerant to antibiotics. It seems that persister cells are the main cause of the recurrence of various chronic infections. Stress response (RpoS-mediated), Toxin-Antitoxin (TA) systems, inhibition of ATP production, Reactive Oxygen Species (ROS), efflux pumps, bacterial SOS respo Read More
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SARS-CoV-2 Infection and Severity in Patients with Hematologic Malignancies: A Systematic Review
Authors: SeyedAhmad SeyedAlinaghi, Amirali Karimi, Pegah Mirzapour, Roghayeh Salmani, Armin Razi, Hengameh Mojdeganlou, Paniz Mojdeganlou, Mohammad Qodrati, Reyhaneh Jashaninejad, Parinaz Paranjkhoo, Omid Dadras, Besharat Zarezadeh, Amir M. Afsahi, Arian Afzalian, Sanaz Varshochi, Esmaeil Mehraeen and Ghazaleh AfsahiIntroduction: Earlier reports described the possibility of higher SARS-CoV-2 infection and severity in patients with hematological malignancies. Given the importance and incidence of these malignancies, we aimed to systematically review SARS-CoV-2 infection and severity in patients with hematologic cancers. Methods: We retrieved the relevant records by searching the keywords in online databases of PubMed, Web of Sci Read More
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Biochemical, Serological and Immunological Tests for Diagnosis of Coronavirus Disease 2019 (COVID-19) Patients: A Comprehensive Systematic Review and Meta-analysis
Authors: Milad Azami, Amirreza Jamshidbeigi, Hadi E. G. Ghaleh and Reza RanjbarBackground: Recent studies have suggested the role of primary laboratory tests in addition to clinical symptoms for patients suspected to have coronavirus disease 2019 (COVID-19), which play a significant role in the diagnosis of COVID-19. However, the results of these studies are contradictory. The present study was conducted to evaluate biochemical, serological, and immunological tests for the diagnosis of COVI Read More
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Toxin-antitoxin Genes Expression in Multidrug-resistant Mycobacterium tuberculosis Isolates under Drug Exposure
Authors: Azar D. Khosravi, Mohammad Savari, Saeed Khoshnood, Fatemeh Shahi and Zahra FarshadzadehIntroduction: Toxin–antitoxin systems (TAs) are highly conserved in Mycobacterium tuberculosis (Mtb). The TAs role in maintaining and disseminating drug resistance in bacterial populations has been indicated. So, we aimed to analyze the expression level of mazEF-related genes in drugsusceptible and multidrug-resistant (MDR) Mtb isolates under isoniazid (INH) and rifampin (RIF) stress. Methods: We obtained 23 Mtb Read More
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Leptotrichia trevisanii: Case Report and Review of the Literature on Patients with Leptotrichia trevisanii Bacteremia in Acute Myeloid Leukemia
Authors: Awad Chady, Garrastegui-Mercado Emmanuel and Suresh AntonyBackground: Leptotrichia spp. are fastidious facultative anaerobic, pencil-shaped, gramnegative rods that reside in the mouths, intestines, and female genital tracts of humans. Bacteremia and septic shock have been rarely reported in the immunocompromised host. We report a case of L. trevisanii bacteremia in a patient recently diagnosed with acute myeloid leukemia (AML) on chemotherapy. Case Presentation: A 75-year Read More
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Hand, Foot, and Mouth Disease Outbreak What You Need to Know
Authors: Amandeep Singh, Okesanya O. John and Bello Barakat BisolaHFMD is an obvious disease in children mostly below the age of five constituting a public health challenge to Asian-Pacific and developing countries majorly. This disease is often caused by enterovirus 71 (EV71) and Coxsackievirus A16. HFMD is a mild degree fever and general illness which manifests for about 10 days. Young age, male gender, poor hygiene, and high social contacts are some risk factors. HFMD can be diagn Read More
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Giardiasis in an Infant With Fibrosarcoma: A Case Report
Authors: Twishi Shrimali, Saumya Srivastava, Naila Mohammad, Nikhil John, Vibhor Tak and Rahul SaxenaIntroduction: Giardia lamblia is a neglected parasitic infection that typically affects the developing nations of the world. It is a microscopic intestinal parasite that is known to cause stomach cramps, bloating, nausea and bouts of diarrhoea. Case Presentation: Here, we are presenting the case of a 1.5 years-old-baby with an immunocompromised condition who got infected by Giardia lamblia. The baby with fibrosarcoma was recei Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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