Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) - Volume 16, Issue 2, 2016

Ebola virus (EBOV) arise attention for their impressive lethality by the poor immune response and high inflammatory reaction in the patients. It causes a severe hemorrhagic fever with case fatality rates of up to 90%. The mechanism underlying this lethal outcome is poorly understood. In 2014, a major outbreak of Ebola virus spread amongst several African countries, including Leone, Sierra, and Guinea. Although infection Read More

Purpose: Escherichia coli are the most frequent cause of gram negative bloodstream infection. This study was done to evaluate the association of risk factors, antimicrobial susceptibility pattern and detection of TEM, SHV and CTX M genes in the extended spectrum beta lactamase (ESBL) producing E.coli. Materials and Methods: 11,133 blood samples were processed in BacT/Alert bottles. Bacteria grown were identified and Read More

Objective: Evaluation of anti-tubercular therapy on endometrium in Female Genital Tuberculosis. Method: Total of 50 women having FGTB on endometrial aspirate (positive AFB, epithelioid granuloma, positive PCR, laparoscopy or hysteroscopy findings) were enrolled. Ultrasound was performed for endometrial thickness, mean resistive index and pulsatility index before and after anti-tubercular therapy (ATT). Diagnosti Read More

Background: Quickness of diagnosis and getting results in prisons is lower than other settings. The present study aimed to assess the quickness of HIV and Tuberculosis diagnostic process in the Great Tehran Prison. Materials and Methods: The present study evaluated the quickness of HIV diagnostic testing (ELISA, Western Blot and CD4 count) in the Great Tehran Prison over the period of October 2013 to May 2014. Also, all Read More

Objective: The aim of this study was to report the epidemiological, clinical and laboratory profiles of HIV-infected patients who admitted to HIV/AIDS laboratory of Imam Khomeini Hospital in Tehran, Iran. Methods: HIV positive patients referred to the HIV/AIDS reference laboratory between December 2012 to March 2013 were included in the study. Their demographic characteristics, behavioral and personal history were ass Read More

Malaria is a parasitic disease, widespread along the tropical regions of the world. The disease has killed 4, 38,000 individuals in the year 2015 (WHO). The malaria parasite, Plasmodium falciparum, has evolved resistance to front-line antimalarials over the decade, necessitating the identification of new drug targets. Protein kinases are excellent drug targets since they participate in critical cell-signaling cascades. We Read More

Urinary tract infections are one of the leading cause of morbidity in admitted patients. Most commonly caused by Escherichia coli, but there are some variants which are commonly reported in urinary tract infection. This study was about to speciate such isolate like E.fergusonnii and find out its antibiogram.