Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) - Volume 15, Issue 3, 2015

Objectives: Polyphenols constitute the major component in green tea, which represent a cluster known as catechins. The presence of polyphenols, especially the amino acid theanine and catechins with its antioxidant properties in green tea make them ideal for medicinal- dental applications. The objective of the paper is to delineate the role of green tea polyphenols in periodontal disease. Methods: The Pub med data base was Read More

Tributylstannic[3-(3,5 -dimethylphenylamido)propionate] is synthesized and characterized by elemental analysis, FT-IR, multinuclear NMR (1H, 13C and 119Sn) and mass spectrometry. The organic anion was found to act as monodentate O-bound ligand in solution. The compound was screened for the anti-HCV potency by the Gaussia luciferase Assay using infected Huh 7.5 cells (human hepatocellular cell) and is found active aga Read More

Acute obstructive pyelonephritis (AOP) is a urological life-threatening inflammatory condition that initially requires immediate urinary drainage and simultaneous prescribing of highly effective targeted antibacterial treatment. The empirical antibacterial therapy is always prescribed before urine culture and susceptibility testing are done. Percutaneous nephrostomy (PNS) and ureteral stenting (US) are the two options for urinary d Read More

Background: Bloodstream infections (BSI) caused by various Candida spp. are a significant cause of morbidity and mortality in hospitalized patients. An increasing proportion of device- related infections, particularly those involving the bloodstream and urinary tract, are being caused by Candida spp. Aims and objectives: This study was conducted to evaluate the different species of Candida causing blood stream infections and the Read More

Adequate adherence to anti-retroviral therapy is required to achieve viral suppression and desirable treatment outcomes among HIV patients. The aim of this study was to examine the associations between adherence and severity of substance use as well as adherence and severity of depressive symptoms among Iranian HIV patients. In a prospective study, HIV patients with current substance use were assessed for ad Read More

Background: Acinetobacter species are ubiquitous in the environment and are important causative agent for nososcomial infection especially in immunocompromised patients. Multi drug resistant Acinetobacter lwoffii are emerging as a pathogen in neoanatal sepsis. Aims and Objective: This study was aimed to evaluate the clinical and antibiotic profile of Acinetobacter lwoffii. Material and Methods: This study was done on blo Read More

Background: Beta Thalassemia is inherited anemia characterized by absent or reduced synthesis of β-globin chains of hemoglobin, caused by β-globin gene mutations resulting in chronic hemolytic anemia that requires ‘repeated blood transfusion with resulting iron overload’. Silymarin has iron chelating activity in thalassemic patients with iron overload. Aim of the work: was to study the therapeutic value of combined thera Read More

Objectives and Aims: Escherchia coli isolated, from urine samples were studied for their antibiotic susceptibility patterns, with special reference to the new antimicrobial compound fosfomycin and their correlation with various virulence factors. Material and Methods: The mid stream urine samples received in the department were processed and identification was done by using the standard culture and identification techniq Read More

We report a case of Coccidioidomycosis of the cranium that presented as a cystlike structure with adjoining bone destruction in a 40-year-old patient with underlying rheumatoid arthritis that was treated with a combination of lipid amphotericin B and longterm fluconazole. We also discuss the common risk factors and presentations of this unusual extra-pulmonary form of Coccidioidomycosis.