- Home
- A-Z Publications
- Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders)
- Previous Issues
- Volume 13, Issue 4, 2013
Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) - Volume 13, Issue 4, 2013
Volume 13, Issue 4, 2013
-
-
Considerations on the Mechanism of Action of Artemisinin Antimalarials: Part 1 - The 'Carbon Radical' and 'Heme' Hypotheses
Authors: Richard K. Haynes, Kwan-Wing Cheu, David N'Da, Paolo Coghi and Diego MontiThe isolation of artemisinin from the traditional medicinal herb qīng hāo (Artemisia annua), its characterization as a peroxide and preparation of the derivatives dihydroartemisinin, artemether and artesunate in the 1970s and 1980s by Chinese scientists under the umbrella of Project 523 collectively represents one of the great events in medicine in the latter third of the 20th Century. Artemisinins have become the most im Read More
-
-
-
Update on Diagnostic and Treatment of Uncomplicated and Complicated Malaria in Adults and Selected Vulnerable Populations
Authors: Philip Botha, Emmanuel Bottieau, Olalekan Uthman, Ude Obike and Jean B. NachegaAlthough malaria remains one of the most important infectious causes of morbidity and mortality world-wide with 40% of the global population at risk, significant progress has been made toward elimination, notably with the development and use of rapid diagnostic tests, insecticide-treated bed nets, indoor residual spraying, and artemisinin-based combination therapies (ACTs). P. falciparum infection remains the most common c Read More
-
-
-
Discovering and Developing New Medicines for Malaria Control and Elimination
More LessA steady increase in the number of antimalarial drug candidates since 2007 follows a call to eradicate malaria from the World Health Organization (WHO), the Bill and Melinda Gates Foundation and others. Four new fixed dose combination medicines have been approved by stringent authorities or the WHO in as many years. OZ439, a synthetic endoperoxide currently in Phase II, could reduce treatment to a single dose. Significan Read More
-
-
-
Malaria in Children - Prevention and Management
Authors: Angela Dramowski, Lisa Frigati, Helena Rabie and Mark CottonMalaria causes a quarter of all childhood deaths in Sub-Saharan Africa. Considerable gains in global malaria control have been achieved in the last decade but coverage of effective interventions remains low in areas of greatest malaria burden. Some countries have achieved reduced malaria related mortality through application of recent advances in malaria prevention and treatment of children. Artemisinin combination thera Read More
-
Volumes & issues
-
Volume 25 (2025)
-
Volume 24 (2024)
-
Volume 23 (2023)
-
Volume 22 (2022)
-
Volume 21 (2021)
-
Volume 20 (2020)
-
Volume 19 (2019)
-
Volume 18 (2018)
-
Volume 17 (2017)
-
Volume 16 (2016)
-
Volume 15 (2015)
-
Volume 14 (2014)
-
Volume 13 (2013)
-
Volume 12 (2012)
-
Volume 11 (2011)
-
Volume 10 (2010)
-
Volume 9 (2009)
-
Volume 8 (2008)
-
Volume 7 (2007)
-
Volume 6 (2006)
Most Read This Month
Article
content/journals/iddt
Journal
10
5
false
en
