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- Volume 24, Issue 6, 2024
Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders) - Volume 24, Issue 6, 2024
Volume 24, Issue 6, 2024
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Interleukin-38 and Insulin Resistance
Authors: Kamil Klejbuk and Marek StrączkowskiInsulin resistance, i.e., decreased biological response to insulin, is a risk factor for many diseases, such as obesity, type 2 diabetes (T2DM), cardiovascular disease, polycystic ovary syndrome, some forms of cancer and neurodegenerative diseases. One of its main causes is chronic low-grade inflammation, mediated by the proinflammatory pathways, such as the c-Jun N-terminal kinase (JNK) pathway and the nuclear fac Read More
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Neonatal Microbiome: Is it Still Beneficial?
Authors: Mohamed Shawky Elfarargy, Dalia Hamdy Elbadry, Ahmad R. Ahmad and Hany A. ElhadyThe neonatal microbiome includes all the microorganisms living within or on the surface of the newborn, as well as their genes (i.e., bacteria, fungi, and viruses), which are composed mainly of bacteria. The majority of these microorganisms reside in the gastrointestinal tract (GIT), which is known as the gut microbiome. They include trillions of microbes, which exceed the total number of neonate cells. In this study, we have Read More
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Role of Polyphenols, their Nano-formulations, and Biomaterials in Diabetic Wound Healing
Authors: Nasr A. Emad, Iqra Zai, Saeem Ahmad, Jayamenti Pandit, Mohd A. Khan and Yasmin SultanaA diabetic wound is one of the major complications arising from hyperglycemia, neuropathy, and oxidative stress in diabetic patients. Finding effective treatments for diabetic wounds has been difficult owing to the complex pathophysiology of diabetic wound environments. Chronic wounds are notoriously difficult to treat with conventional wound care methods. In recent years, polyphenols found in plants have received muc Read More
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Current Views About the Link between SARS-CoV-2 and the Liver: Friends or Foe?
The emergence of the novel coronavirus and the pandemic resulting from its spread have led to significant negative impacts on health, economy, relationships, and others. Particularly in the field of hospital care, the need for a greater number of patients has led to a breakdown of the system. Gastrointestinal manifestations are common in SARS-COV 2 patients, while 10% of those who are sick exhibit symptoms only from gastr Read More
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Eicosapentaenoic Acid: between Cardiovascular Benefits and the Risk of Atrial Fibrillation
In recent years, scientific research has increasingly focused on the cardiovascular benefits of omega-3 polyunsaturated fatty acids (n-3 PUFAs) supplements. The most promising results emerged from the new trials on a high-dose eicosapentaenoic acid (EPA)-only approach, instead of the previously prescribed therapy with EPA + docosahexaenoic acid (DHA). The evidence of the reduction of cardiovascular events in patien Read More
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Obesity Phenotypes and Dental Calculus in Young Adults: CHIEF Oral Health Study
Aim: The study aimed to examine the association of obesity phenotypes with dental calculus. Background: Obesity has been recognized as a risk factor for kidney and gallbladder stones formation and periodontitis. Objective: We have investigated the association between obesity, metabolic risk factors, and dental calculus, which is a sequela following periodontitis. Methods: This study included 5,281 military members, aged 1 Read More
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Network Pharmacological Analysis and Experimental Validation of the Effects of Silybin on Proliferation, Migration, and Immunotherapy of Papillary Thyroid Cancer
Authors: Wenjun Xie, Huashui Li, Qiang Lin and Naizhuo KeAim: The study aimed to use network pharmacology research and in vitro experiments to investigate the material basis and molecular mechanisms of silybin in the treatment of papillary thyroid carcinoma. Background: Papillary thyroid cancer (PTC) has a decent prognosis; however, recurrence and metastasis are the leading causes of death in patients with PTC. A key research focus in thyroid cancer treatment is the inhibition of Read More
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Huangqin-Huanglian Decoction Protects Liver against Non-alcoholic Fatty Liver Disease in High Fat-diet Mice
Authors: Hongying Yang, Dongyun Wei, Yao Zhang and Wenxuan JianBackground: Traditional Chinese medicine (TCM) has the advantage of low toxicity of natural ingredients, multiple targets and effects, and low medication costs. It has unique advantages for metabolic and chronic diseases. Huangqin-Huanglian decoction (HQHLD) is composed of Scutellariae Radix, Coptidis Rhizoma, Rehmanniae Radix, and Gentianae Radix Et Rhozima; it has great potential for the treatment of NA Read More
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The Effect of Metformin Treatment on Disease Control in Patients with Acromegaly
Authors: Humeyra R. Sahin, Serdar Sahin, Betul Sarac, Cem Sulu, Pinar Kadioglu and Hande Mefkure OzkayaBackground: The increase in portal insulin levels has been shown to upregulate growth hormone receptor expression in the liver, leading to increased insulin-like growth hormone- 1 levels. Metformin inhibits hepatic gluconeogenesis and reduces fasting insulin. Objectives: We evaluated the effect of metformin treatment in patients with acromegaly on growth hormone, insulin-like growth hormone-1, and pituitary adenom Read More
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The Jiangtang Tongmai Prescription Inhibits Inflammation and Fibrosis of Lung Fibroblast Autophagy Induced by Hyperglycemia by Regulating CAV1 Expression
Authors: Nian Ding, Yanbo Fan and Chenghong ZhengObjective: The lung is one of the target organs of diabetes. This study aimed to probe the protective mechanism of Jiangtang Tongmai Prescription (JTTMP) against diabetic lung injury. Methods: JTTMP-containing serum was collected, and a high glucose and high-fat diabetic cell model was established. The cells were treated with a drug-containing serum or a CAV1-associated vector. Transfection efficiency was measured by Read More
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Liraglutide and Liver Injury: Rare Case Report with Literature Review
Authors: Amir M. Salehi, Maryam Hasanzarrini, Hossain Salehi and Ensiyeh JenabiBackground: Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the treatment of type 2 diabetes mellitus (T2DM). So far, few severe side effects have been reported for it. Case Presentation: A 41-year-old woman was admitted to the Emergency Room with diffuse abdominal pain. The patient had a known case of T2DM, fatty liver disease, and hypertension and was treated with Metformin, Liraglutid Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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