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Drug Metabolism and Bioanalysis Letters - Online First
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Understanding DNA and PARP in Cancer: Tackling Inhibitor Resistance
Available online: 08 April 2025More LessDeoxyribonucleic acid (DNA) is the crucial molecule that stores and transmits genetic information in living organisms. DNA can incur damage from various sources, necessitating efficient DNA repair mechanisms to maintain genomic stability. Cells employ multiple repair pathways, including single-strand repair and double-strand break repair, each involving specific proteins and enzymes. PARPs play a fundamental role in the Read More
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Bioanalytical Method Development and Validation for the Estimation of Metformin and Vildagliptin in K3EDTA Human Plasma Using HPLC-ESI-MS/MS
Authors: Binit Patel, Shalin Parikh, Ravi Patel, Khushbu Patel, Pinak Patel, Pravinkumar Darji, Archita Patel and Samir PatelAvailable online: 19 March 2025More LessObjective A unique liquid chromatography-tendon mass spectrometric technique for the determination of metformin and vildagliptin in K3EDTA human plasma was developed and verified as per the USFDA guidelines of bioanalysis. Methods The chromatographic separation was achieved using a Cosmosil CN (150 x 4.6 mm, 5 µm) column with an isocratic elution pattern using 10 mM ammonium formate (pH 5.0) and meth Read More
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Sphingolipids in Cancer: Metabolism, Signaling, and Clinical Implications
Authors: Sharav A. Desai, Sandip D. Nagare, Vipul P. Patel, Nishant B. Pagare and Tejas C. JangamAvailable online: 26 February 2025More LessSphingolipids are bioactive lipids that are essential for cellular functions like signaling, apoptosis, and proliferation. They are also important in the biology of cancer. The complex dynamics of sphingolipid metabolism and its consequences for the advancement of cancer are examined in this review. It highlights the regulatory functions of important enzymes such as ceramide kinase (CERK) and sphingosine kinases (SPHKs) in Read More
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